激酶谱筛选目录

1 抗肿瘤新药分子水平筛选 

 1.2 酪氨酸激酶Kinase抑制剂分子水平筛选

     Abl-1, Abl-1 (T315I), Abl-1 (H396P), Abl-1 (M351T), Abl-1 (Q252H)，Abl-1 (Y253F), ACK1, ALK, ALK4, Axl, BLK, BMX, BRK, BTK, CSK, c-Met, c-Met (D1246H), c-Met (M1268T), c-Met (Y1248C), c-Met (Y1248D), c-Met (Y1248H), c-Kit, c-Kit (D816V) , c-Kit (V560G) , c-Kit (V654A), DDR1, DDR2, EGFR, EGFR(L858R),EGFR (T790M) , EGFR (L858R/T790M), EphA1, EphA2,EphA3, EphA4, EphA6, EphB2, EphB3, EphB4, FAK, FES, FGR，FGFR1 (V561M), FGFR1 (FLT2) , FGFR2, FGFR3, FGFR4,F1t1 (VEGFR1) ,Flt3, FMS (CSF1R) , FRK, FYN, HCK, Her2, Her4, IGF-1R, Insulin Receptor, ITK, JAK1, JAK2, JAK3, LCK, LYN-A, LYN-B, MUSK, NTKR1 (TRKA),NTKR2 (TRKB) , NTKR3(TRKC), PDGFRa , PDGFR3 , PYK2, RET,RON, ROR1, ROR2, ROS1, Src, Syk, Tie2, TXK, Tyk2,TYR03, VEGFR2/KDR, VEGFR3, YES1, ZAP70, RIPK1, PIM-1, Sphk1, Sphk2, AMPK, GSK-3β, CK1, CK2, LRRK2, RSK4;

 1.3 丝/苏氨酸激酶Kinase抑制剂分子水平筛选

Akt1, Akt2, Akt3, AMPK, Aurora A, Aurora B, Aurora C, B-Raf, B-Raf (V600E),C-Raf,CaMK,CDK1/CyclinA2,CDK2/CyclinA2,CDK2/CyclinE1,CDK3/CyclinE1,CDK4/CyclinD3,CDK4(EE,T172A)/CyclinD1,CDK5/p25,CDK5/p35,CDK6/CyclinD1,CDK6/CyclinD3,CDK7/CyclinH1/MNAT1, CDK9/CyclinK, CHK1,CHK2, ERK1, ERK2, JNK1, JNK2, JNK3, MEK1, MEK2，MLCK, mTOR, PI3 Kinase (p110a/p85a),PI3 Kinase(p110p/p85a),PI3Kinase(p1105/p85a),PI3Kinase(p110a(E542K)/p85a) PI3 Kinase (p110a(E545K)/p85 a), PI3 Kinase (p110a(H1047R)/p85 a),PI3 Kinase (p110a/p65a), p38, p70S6K, PKA, PKC, PKD, PLK1, PLK2, PLK3, ROCK1 ,ROCK2, ROCK3, RIPK1, PIM-1, Sphk1, Sphk2, AMPK, GSK-3β, CK1, CK2, LRRK2, RSK4;